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mitotane will minimize the extent or impact of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of abemaciclib with powerful CYP3A4 inducers minimizes plasma focus of abemaciclib and its metabolites.Abemaciclib targets CDK4 and CDK6, proteins that assistance control mobile d